Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2197 | CA7970 | U.S. | 1998 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 112 |
| 2 | 3TC+ AZT+ RTV | 39 |
| 3 | 3TC+ D4T+ IDV | 100 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SS, K70R, M184V | A62V | A98S, D123E, D177E, G196R, Q207E, R211K, V245K | Q85QH |
| >CA7970| codons 1-258 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSSRWRKLVDFRELNKRTHDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIRQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQ |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | N88D | L10I, I15V, L19M, K20M, M36MI, L63P, H69Q, A71AV, V77I, I93L |
| >CA7971| codons 1-99 PQITLWQRPIVTIKVGGQMMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKVIGTVLIGPTPANIIGRDLLTQLGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |