Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA26353 | CA79455 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDI+NFV | 104 |
| 2 | 3TC+D4T+NFV+NVP | 104 |
| 3 | 3TC+D4T+FPV+NVP | 74 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54L, L90M | L10F, L33F, N88D | I13V, K14R, I15V, K20T, E35D, M36I, R41I, K43RS, R57K, I62V, L63P, I66V, A71V, I72T, V77I, Q92K, I93L, C95F, T96S |
| >CA79455| codons 1-99 PQITLWQRPFVTVRVGGQLTEALLDTGADNTVFEDINLPGIWSPKMIGGIGGFLKVKQYD QVPIEVCGHKVTGTVLIGPTPVNIIGRDLMTKLGFSLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74I, M184V, L210W, T215F | K219W | Y181C | K101H, V108I | V35K, T39A, K43E, V118I, K122KE, D123E, I135T, Q174QH, G196E, Q207E, H208Y, R211K, L228K, V245K, A272P, K277R, T286A, E297K |
| >CA79456| codons 1-309 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALKEICAELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI CQYVDDLYVGSDLEIEQHRTKIEELREYLWKWGFFTPDWKHQKEPPFKWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTEVIPLTKEAE LELAENREI |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 protease mutations and protease inhibitor cross resistance. | AAC, 2010 |