Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA6031 | CA79362 | U.S. | 2007 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 126 |
| 2 | 3TC+AZT | 65 |
| 3 | DDI+NFV+NVP | 87 |
| 4 | DDI+RTV+SQV | 52 |
| 5 | ABC+APV+D4T+DDI+RTV | 152 |
| 6 | ABC+APV+DDI+RTV+TDF | 87 |
| 7 | ABC+DDI+FPV+RTV+TDF | 119 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K70A | V35I, T39A, E40F, K43E, A98S, V111VIM, V118I, K122E, I135T, I142IV, G196E, H208Y, R211K, I293V |
| >CA79362| codons 1-294 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICAFLEEEGKISKIGPENPYNTPV FAIKKKNSTAWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDMGDAYFSIPL DEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, I54L, I84V, L90M | L10F, L33F, N88D | I13V, K45R, L63P, I66IV, P79PS, L89LF, I93L, C95CF |
| >CA79361| codons 1-99 PQITLWQRPFVTVKIGGQLKEALLDTGADNTVFEEMNLPGRWKPRMIGGIGGFLKVRQYD QIPIEVCGHKAIGTVLVGSTPVNVIGRDFMTQLGFTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D3E, S24G, D25E, S39C, L45V, K211R, S230N |
| >CA124201| codons 1-288 FLEGIDKAQEEHEKYHSNWRAMAGEFNLPPVVAKEIVACCDKCQVKGEAMHGQVDCSPGI WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIATDIQTRELQKQITKIQNFRVYYRDNRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |