<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
510-35 510-35W14 U.S. 1996 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 D4T+NFV 14

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I T74P T12K, I15V, L19I, M36I, N37S, R41K, D60E, I62V  
>510-35W14| codons 1-99
PQITLWQRPLVKIKVGGQIKEALLDTGADDTVLEEISLPGKWKPKIIGGIGGFIKVRQYE
QVLIEICGHKAIGPVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Patick, AK Genotypic and phenotypic characterization of human immunodeficiency virus type 1 variants isolated from patients treated with the protease inhibitor nelfinavir. AAC, 1998
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005