Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2073 | CA79310 | U.S. | 2006 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+DDC | 48 |
| 2 | AZT+DDC+DDI | 26 |
| 3 | D4T+DDI+SQV | 31 |
| 4 | 3TC+AZT+IDV | 43 |
| 5 | D4T+DDI+IDV | 26 |
| 6 | 3TC+AZT+IDV | 83 |
| 7 | ABC+APV+D4T+EFV | 335 |
| 8 | ABC+D4T+FPV | 76 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, L210W, T215Y | K219N | K103N | V108I, Y181G | E6D, T27S, K43E, E44A, V90I, V118I, K122E, I142V, A158S, S162HY, V189VI, I202V, H208Y, R211K, H221Y, K223Q, L228R, V245VE, A272P |
| >CA79310| codons 1-300 PISPIDTVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPSIFQYSMTKILEPFRKQNPDIVI GQYMDDLYIGSDLEIGQHRTKVEELRQYLWKWGFYTPDNKYQQEPPFRWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54M, V82A, L90M | L10FI, V11VI | I13V, I15V, Q18QH, K20I, M36I, N37D, L63P, A71IV, I93L |
| >CA79309| codons 1-99 PQITLWQRPIITVKVGGHLIEALLDTGADDTVLEEIDLPGRWKPKLIGGIGGFMKVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| I73V, S119P, T206S, D207E, I208L |
| >CA124181| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI WQLDCTHLEGKIVLVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGPN FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIVDIIASELQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED |
References
| Author | Title | Citation |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |