Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8099 | 8099-30930 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 1 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, L76V, V82A | L24I | L10I, I15V, K20R, M36I, I62V, L63P, A71V, I72T |
| >8099-30930| codons 1-99 PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD QVPIEICGHKVTGTVVVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | T39S, K43E, E44A, K102R, K104R, V118I, K122E, D123N, I142V, R172RK, V179VI, T200A, Q207QE, H208HY, V245E, D250E, R284K, T296S, K311R, G335S, M357T, G359S, V365I, K390R |
| >8099-30930| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICSELEEAGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKRSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIII YQYMDDLYVGSDLEIGQHRAKIEELREYLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVIPLSEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARTRSA HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |