<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8099 8099-30922 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, L76V, V82A L24I L10I, I15V, K20R, M36I, I62V, L63P, A71V, I72T  
>8099-30922| codons 1-99
PQITLWQRPIVTIKVGGQLREALIDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVRQYD
QVPIEICGHKVTGTVVVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L210W, T215Y       T39S, K43E, E44A, K102R, K104R, V118I, K122E, D123N, I142V, R172RK, V179VI, T200A, Q207QE, H208HY, V245E, D250E, R284K, T296S, K311R, G335S, M357T, G359S, V365I, K390R  
>8099-30922| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICSELEEAGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKRSVTVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIII
YQYMDDLYVGSDLEIGQHRAKIEELREYLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGTKALTEVIPLSEEAE
LELAENREILREPVHGVYYDPSKDLIAEIQKQGQSQWTYQIYQEPFKNLKTGKYARTRSA
HTNDIKQLTEAVQKIATESIVIWGKTPKFRLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006