Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8091 | 8091-30926 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73C | I13IM, I15IV, L19Q, K20I, M36MI, N37NS, L63P, I64V, H69R, I72L |
| >8091-30926| codons 1-99 PQITLWQRPFVTMKVGGQQIEALLDTGADDTVLEEISLPGRWKPKIIGGIGGFVKVRQYD QIPVEICGRKALCTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LV, L210W, T215Y | V35L, K43E, S68G, T69N, V118I, K122E, D123N, G196E, R211K, I293V, E297K, I329V, Q334E, G359S, A371V, A376S, K390R |
| >8091-30926| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALLEICTELEEEGKISKIGPENPYNTPV FAIKKKDGNKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGEGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKISTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |