Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8078 | 8078-30923 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L210W, T215Y | K219R | Y188L | V35VI, E44D, V60I, A98S, V118I, K122KE, K173Q, V179I, T200E, E203K, R211K, K223E, L228R, D237E, V245M, D250DE, Q278H, E312Q, A376S, T377R |
| >8078-30923| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPI FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQQNPDIII YQYMDDLLVGSDLEIGQHREKIKELRQHLWKWGFYTPDRKHQEEPPFRWMGYELHPEKWT VQPIMLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGTKALTEVIPLTEEAE LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKISRESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L10F, L24I, L33F, Q58E | I13V, K20R, M36I, R41K, D60E, I62V, L63E, I64V, H69R |
| >8078-30923| codons 1-99 PQITLWQRPFVTVKIGGQLREALIDTGADDTVFEEINLPGKWKPKIIGGIGGFVKVREYE QVEVEICGRKAIGTVVVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |