<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8078 8078-30923 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A L10F, L24I, L33F, Q58E I13V, K20R, M36I, R41K, D60E, I62V, L63E, I64V, H69R  
>8078-30923| codons 1-99
PQITLWQRPFVTVKIGGQLREALIDTGADDTVFEEINLPGKWKPKIIGGIGGFVKVREYE
QVEVEICGRKAIGTVVVGPTPANIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L210W, T215Y K219R Y188L   V35VI, E44D, V60I, A98S, V118I, K122KE, K173Q, V179I, T200E, E203K, R211K, K223E, L228R, D237E, V245M, D250DE, Q278H, E312Q, A376S, T377R  
>8078-30923| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPI
FAIKKKDSDKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRQQNPDIII
YQYMDDLLVGSDLEIGQHREKIKELRQHLWKWGFYTPDRKHQEEPPFRWMGYELHPEKWT
VQPIMLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGTKALTEVIPLTEEAE
LELAENREILKQPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKISRESIVIWGKTPKFKLPIQKETWEA

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006