Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8077 | 8077-30818 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K103N | Y318F | E44D, A98S, D123E, I135IL, E138Q, K166R, D177E, I178IL, G196E, T200A, E203D, Q207K, R211A, A272P, I293V, I326V, I329V, G335S, K347Q, A371V, A376S, T386I, K390R |
| >8077-30818| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSLNNQTPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPELVI YQYVDDLYVGSDLEIEQHRAKIDELRKHLWAWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVFYDPSKDLVAEVQKQGQSQWTYQIYQEPFQNLKTGKYARMRGA HTNDVKQLTEVVQKISTESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L10FI, L24I, L33F | K20R, E35D, M36I, I62V, L63P, I64L, A71V, V77I, T91S, I93L |
| >8077-30818| codons 1-99 PQITLWQRPIVTIKIGGQLREALIDTGADDTVFEDINLPGRWKPKLIGGIGGFVKVRQYD QVPLEICGHKVIGTVLIGPTPANIIGRNLLSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |