Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8076 | 8076-30925 | U.K. | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V | Q58E | L10I, I13V, K14R, I15V, K20I, E35N, M36I, N37D, R57RK, L63P, H69K, V82I, L89M | D60Q |
| >8076-30925| codons 1-99 PQITLWQRPIVTVRVGGQLIEALLDTGADDTVLENIDLPGRWKPKIIGGIGGFVKVKEYQ QIPIEICGKKAIGTVVVGPTPINVIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | V35T, T39A, K43R, E44D, V106VI, V118I, K122E, D123N, S162C, Q174R, D177E, I178M, T200A, E203K, Q207D, H208Y, R211Q, K223Q, L228H, V245Q, D250E, A272P, T286A, E291D, I293V, E297A, D324E, I329V, Q334P, G335E, F346Y, R356K, M357R, R358G, G359S, A371V, A376S, T386I, K390R, Q394R, E399D |
| >8076-30925| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELERDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKRNPEMVI YQYMDDLYVGSDLEIGQHRAKIKELRDYLWQWGFYTPDKKHQQEPPFHWMGYELHPDKWT VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVPLTAEAE LELAENREILKEPVHGVYYDPSKELIAEVQKQGPEQWTYQIYQEPYKNLKTGKYAKRGSA HTNDVKQLTEVVQKISTESIVIWGKIPKFRLPIRKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |