<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8076 8076-30925 U.K. 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, I84V Q58E L10I, I13V, K14R, I15V, K20I, E35N, M36I, N37D, R57RK, L63P, H69K, V82I, L89M D60Q
>8076-30925| codons 1-99
PQITLWQRPIVTVRVGGQLIEALLDTGADDTVLENIDLPGRWKPKIIGGIGGFVKVKEYQ
QIPIEICGKKAIGTVVVGPTPINVIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y       V35T, T39A, K43R, E44D, V106VI, V118I, K122E, D123N, S162C, Q174R, D177E, I178M, T200A, E203K, Q207D, H208Y, R211Q, K223Q, L228H, V245Q, D250E, A272P, T286A, E291D, I293V, E297A, D324E, I329V, Q334P, G335E, F346Y, R356K, M357R, R358G, G359S, A371V, A376S, T386I, K390R, Q394R, E399D  
>8076-30925| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELERDGKISKIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSIPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKRNPEMVI
YQYMDDLYVGSDLEIGQHRAKIKELRDYLWQWGFYTPDKKHQQEPPFHWMGYELHPDKWT
VQPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDVVPLTAEAE
LELAENREILKEPVHGVYYDPSKELIAEVQKQGPEQWTYQIYQEPYKNLKTGKYAKRGSA
HTNDVKQLTEVVQKISTESIVIWGKIPKFRLPIRKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006