<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8073 8073-30729 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, L76V, V82A L33LF L10I, N37D, R41K, I62V, L63P, A71V, I93L  
>8073-30729| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTVFEEMDLPGKWKPKIIGGIGGFVKVRQYD
QVPIEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, K70R, T215FY K219Q     V35M, T39A, E40D, V60VI, V118VI, I142IV, R172RK, D177DE, G196E, E204Q, Q207E, R211K, F214L, L228H, V245VA, Q278H, A288T, V292I, I293V, E297A, I329L, F346Y, G359S, T377L V21VGIS
>8073-30729| codons 1-399
PISPIETVPVKLKPGMDGPKSKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL
DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIEQLREHLLKWGLYTPDQKHQKEPPFHWMGYELHPDKWT
VQPIALPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGTKTLTEIVPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGQGQWTYQIYQEPYKNLKTGKYARMRSA
HTNDVKQLTEAVQKIALESIVIWGKTPKFKLPIQKETWE

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006