Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8056 | 8056-30930 | U.K. | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184MV, T215Y | K103N, Y181C, G190A | S3C, E6D, V35T, T39E, K122E, D123S, I142V, S163I, T165L, K173T, Q174K, D177E, T200A, E203D, Q207E, H208Y, R211K, V245Q, E248D, A272P, K275R, Q278H, K281R, T286A, V292I, I293V, Q334N, G335D, R358K, G359T, A371V, I375V, T377M, K390R, E396D |
| >8056-30930| codons 1-399 PICPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSIMLKILEPFRTKNPEIVI CQYVDDLYVASDLEIGQHRAKIDELREYLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKDSWTVNDIQKLVGKLNWASQIYPGIRVKHLCRLLRGAKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYARMKTA HTNDVKQLTEVVQKVAMESIVIWGKTPKFRLPIQKDTWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47A | L33F, Q58E | L10I, T12S, I15V, L19I, K20T, M36I, D60E, L63P, H69K, T74A, V82I, I85V, L89M, I93L |
| >8056-30930| codons 1-99 PQITLWQRPIVSIKVGGQITEALLDTGADDTIFEEINLPGRWKPKMAGGIGGFIKVREYE QIPIEICGKKAIGAVLVGPTPINIVGRNMLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |