Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8055 | 8055-30915 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L10F, L24I, L33F | E35D, R57K, L63P, A71V, I93L |
| >8055-30915| codons 1-99 PQITLWQRPFVTIKIGGQLKEALIDTGADDTVFEDMNLPGRWKPKIIGGIGGFVKVKQYD QIPIEICGHKVIGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215Y | K219E, N348I | Y181C | V108I | T39A, V60I, R83K, K101Q, V118VI, D123E, D177E, R211K, H221Y, L228R, D237E, A272P, K277R, I293V, E297A, Q334E, P345Q, K390R, K395R, E396D, E399D, A400S |
| >8055-30915| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLQKKKSVTILDVGDAYFSIPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFYTPDEKYQKEPPFRWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGEGQWTYQIYQEQFKILKTGKYARMRGA HTNDVKQLTEAVQKIATESIVIWGKTPKFRLPIQRDTWDS |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |