Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8053 | 8053-30818 | U.K. | 2003 | HIV1 | A | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, Y115F, Q151M, M184V | A62AV, V75I, F116Y, K219Q | K101E, G190GS | P4H, K11T, K32KR, V35T, T39A, V60I, V118VI, K122E, D123N, K173S, Q174K, D177E, V179I, Q207A, R211S, F214FL, V245Q, I293V, P294T, G335D, M357K, R358K, G359S, K366R, A371V, I375V, T377Q | A33IV |
| >8053-30818| codons 1-399 PISHIETVPVTLKPGMDGPKVKQWPLTEEKIRVLTEICAEMEKEGKISKIGPENPYNTPI FVIKKKNSDKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAFYSIPL DENFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRSKNPEIII YQYVDDLYVSSDLEIGQHRTKIEELRAHLLSWGLTTPDQKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVTLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQDQWTYQIYQEPFKNLKTGKYARKKSA HTNDVRQLTEVVQKVAQESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54S, V82A | L33I, F53L | L10I, I13A, K14N, A22V, E35D, M36I, K55R, R57K, I62V, L63P, H69K, K70KR, T74S, L89I |
| >8053-30818| codons 1-99 PQITLWQRPIVTANIGGQLKEVLLDTGADDTVIEDINLPGRWKPKLIVGIGGLSRVKQYD QVPIEICGKRAIGSVLVGPTPANIIGRNILTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |