Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8051 | 8051-30924 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, T215Y | K101E, G190A | S3C, E6K, K20R, K22R, E28K, V35E, T39A, K122E, D123E, V179I, T200A, Q207E, L210F, D237E, A272P, I293V, D324E, Q334L, R356K, G359GS, E370D, A371AV, S379SC, K390R, E399ED, A400AT |
| >8051-30924| codons 1-400 PICPIKTVPVKLKPGMDGPRVRQWPLTKEKIKALEEICAELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKIVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYVDDLYVASDLEIGQHRAKIEELREHLFRWGFYTPDKKHQKEPPFLWMGYELHPEKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTDVVQKIATECIVIWGKTPKFRLPIQKETWDT |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L76V, V82F, L90M | L33F, Q58E, G73S, L89V | L10I, I13V, R57K, Q61H, I62V, L63P, A71T, T74K, V77I, I93L |
| >8051-30924| codons 1-99 PQITLWQRPIVTVKIGGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFIKVKEYD HVPIEICGHKTISKVVIGPTPFNIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |