<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8036 8036-30808 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, V75M, L210W, T215F K219W Y181C V179D P4PS, K43E, E44A, V60I, K103R, V111I, V118I, K122E, D123E, I142V, A158T, T200TA, H208Y, R211K, D218E, P243S, A272P, K277R, I293V, E297A, S322T, D324E, K350R, G359S, V365I, A371V, A376S, T386I, K390R  
>8036-30808| codons 1-399
PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI
FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDIGDAYFSIPL
DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPTIFQSSMTKILEPFRKQNPDIDI
CQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFFTPEWKHQKEPPFLWMGYELHPDKWT
VQSIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE
LELAENREILKEPVHGVYYDPTKELIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRSA
HTNDIKQLTEVVQKISTESIVIWGKIPKFRLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I50V, I54V, V82A, L90M L10F I15V, G16GA, K20R, E35D, M36I, L63P, A71V, I72IV, I93L  
>8036-30808| codons 1-99
PQITLWQRPFVTIKVAGQLREALLDTGADDTVLEDINLPGRWKPKIIGGVGGFVKVRQYD
QIPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006