Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8036 | 8036-30808 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L10F | I15V, G16GA, K20R, E35D, M36I, L63P, A71V, I72IV, I93L |
| >8036-30808| codons 1-99 PQITLWQRPFVTIKVAGQLREALLDTGADDTVLEDINLPGRWKPKIIGGVGGFVKVRQYD QIPIEICGHKVVGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, L210W, T215F | K219W | Y181C | V179D | P4PS, K43E, E44A, V60I, K103R, V111I, V118I, K122E, D123E, I142V, A158T, T200TA, H208Y, R211K, D218E, P243S, A272P, K277R, I293V, E297A, S322T, D324E, K350R, G359S, V365I, A371V, A376S, T386I, K390R |
| >8036-30808| codons 1-399 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDIGDAYFSIPL DEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPTIFQSSMTKILEPFRKQNPDIDI CQYMDDLYVGSDLEIGQHRAKIEELRQYLWKWGFFTPEWKHQKEPPFLWMGYELHPDKWT VQSIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTAEAE LELAENREILKEPVHGVYYDPTKELIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRSA HTNDIKQLTEVVQKISTESIVIWGKIPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |