Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8033 | 8033-30514 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A | Q58QE | L10I, I13IV, I15V, K20R, E35D, M36I, R41K, D60E, L63P, L89M, I93L |
| >8033-30514| codons 1-99 PQITLWQRPIVTVKVGGQLREALLDTGADDTVLEDINLPGKWKPKIIGGVGGFVKVREYE QIPIEICGHKAIGTVLVGPTPANIIGRNMLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210L*W, T215F | N348I | K101DEHQ, G190S | T39TA, V60VI, V118I, V179I, R206RK, R211K, F214L, K277R, I293V, E297K, V317A, I326V, Q334L, A360AT, A371V, I375V, T377R, K390R |
| >8033-30514| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICAELEKEGKISKIGPENPYNTPI FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIII YQYMDDLYVSSDLEIGQHRTKIEELKQHLWKWGLFTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGAYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKILKTGKYARMRGT HTNDVKQLTEVVQKVARESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |