Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8032 | 8032-30707 | U.K. | 2003 | HIV1 | C | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90LM | T12S, I15V, L19I, M36I, R41K, L63P, H69K, K70KR, V82I, I93L |
| >8032-30707| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD QIPIEICGKRAIGTVLVGPTPINIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67DN, K70KEGR, T215SY | G190A | V35T, T39E, S48T, V90VI, K102KR, K122E, D123DGNS, K173AT, D177E, I178M, T200TA, Q207A, K249KQ, D250DE, A272P, K277R, E291D, V292I, I293V, L295M, Q334N, G335D, R356K, G359T, T386I |
| >8032-30707| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICEEMEKEGKITKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEMVI YQYMDDLYVASDLEIGQHRAKIEELRAHLLRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEQESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTDIVPMTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGNDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKIATESIVIWGKIPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |