Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8031 | 8031-30616 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, T215Y | K219E | L100I, K103N | V35T, K43E, E44A, K64KR, A98S, V118I, K122E, D123E, S162D, S163SR, T200E, E203K, Q207A, H208Y, L210S, D218E, L228H, Q242H, V245Q, D250E, A272P, K277R, L283I, V292I, I293V, G333E, A355AG, R356K, M357IL, I375V, T377R, S379C, K390R, A400AS | I159IL, D177DGNS |
| >8031-30616| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEEAGKISKIGPENPYNTPV FAIRKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPALFQDRMTKILEPFRKQNPSIVI YQYVDDLYVGSDLEIGQHREKIKELRAYLSRWGFYTPEEKHQKEPPFHWMGYELHPDKWT VHPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYGKLRGA HTNDVKQLTEAVQKVARECIVIWGKTPKFRLPIQKETWES |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | K43KT | I62IV, L63P, A71AT, I72IM, V77I |
| >8031-30616| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWTPKMIGGIGGFIKVRQYD QVPIEICGHKTMGTVLIGPTPVNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |