<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8031 8031-30616 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, M184V, T215Y K219E L100I, K103N   V35T, K43E, E44A, K64KR, A98S, V118I, K122E, D123E, S162D, S163SR, T200E, E203K, Q207A, H208Y, L210S, D218E, L228H, Q242H, V245Q, D250E, A272P, K277R, L283I, V292I, I293V, G333E, A355AG, R356K, M357IL, I375V, T377R, S379C, K390R, A400AS I159IL, D177DGNS
>8031-30616| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEEAGKISKIGPENPYNTPV
FAIRKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPSGIKKNKSVTVLDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPALFQDRMTKILEPFRKQNPSIVI
YQYVDDLYVGSDLEIGQHREKIKELRAYLSRWGFYTPEEKHQKEPPFHWMGYELHPDKWT
VHPIQLPEKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTKALTEIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEQGQWTYQIYQEPFKNLKTGKYGKLRGA
HTNDVKQLTEAVQKVARECIVIWGKTPKFRLPIQKETWES

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
L90M K43KT I62IV, L63P, A71AT, I72IM, V77I  
>8031-30616| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWTPKMIGGIGGFIKVRQYD
QVPIEICGHKTMGTVLIGPTPVNIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006