Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8029 | 8029-30509 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67~, K70R, L74V, T215F | T69G, K219Q | A98G | V35M, T39A, K43E, K122E, I135L, D177N, V179I, D218E, A288AS, I293V, E297A, L325I, I326V, I329V, G359S, A371V, T377L, T386TI, K390KR, E399D |
| >8029-30509| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEEEGKISKIGPENPYNTPV FAIKKK~SGRWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIII YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKSLTEVVPLTAEAE LELAENREILKEPVHGVYYDPSKDIVAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIALESIVIWGKIPKFRLPIQKETWDA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | V32L, L89V | L10I, I15V, K20R, E35D, N37T, R41K, K55R, R57K, Q61N, L63A, A71V, I85IV, Q92K |
| >8029-30509| codons 1-99 PQITLWQRPIVTIKVGGQLREALLDTGADDTLLEDMTLPGKWKPKIVGGIGGFVRVKQYD NIAIEICGHKVIGTVLVGPTPANIVGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |