<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8024 8024-30815 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y K219N K103KN, Y181C V108I E6K, K20R, V21I, V35I, E40F, K43E, K101KR, V118I, K122E, D123E, K166Q, Q174K, N175Y, E194K, G196E, Q197E, I202V, R211K, A272P, K277R, I293V, E297K, D324E, R358K, A376T, T386A, E396D  
>8024-30815| codons 1-399
PISPIKTVPVKLKPGMDGPRIKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV
FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKNKSVTILDVGDAYFSIPL
DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTQILEPFRKKYPDIVI
CQYVDDLYVGSDLKIEEHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA
HTNDVKQLTEAVQKITTESIVIWGKAPKFKLPIQKDTWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54V, V82A, L90M L33F, K43T, F53L, T74P L10V, I13V, K20R, E35D, M36I, R41K, K55R, I62V, L63P, A71V  
>8024-30815| codons 1-99
PQITLWQRPVVTVKIGGQLREALLDTGADDTIFEDINLPGKWTPKIVGGIGGLVRVRQYD
QVPIEICGHKVIGPVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006