Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8024 | 8024-30815 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | L33F, K43T, F53L, T74P | L10V, I13V, K20R, E35D, M36I, R41K, K55R, I62V, L63P, A71V |
| >8024-30815| codons 1-99 PQITLWQRPVVTVKIGGQLREALLDTGADDTIFEDINLPGKWTPKIVGGIGGLVRVRQYD QVPIEICGHKVIGPVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219N | K103KN, Y181C | V108I | E6K, K20R, V21I, V35I, E40F, K43E, K101KR, V118I, K122E, D123E, K166Q, Q174K, N175Y, E194K, G196E, Q197E, I202V, R211K, A272P, K277R, I293V, E297K, D324E, R358K, A376T, T386A, E396D |
| >8024-30815| codons 1-399 PISPIKTVPVKLKPGMDGPRIKQWPLTEEKIKALIEICTFLEEEGKISKIGPENPYNTPV FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLRKNKSVTILDVGDAYFSIPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTQILEPFRKKYPDIVI CQYVDDLYVGSDLKIEEHRTKVEELRQHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKGA HTNDVKQLTEAVQKITTESIVIWGKAPKFKLPIQKDTWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |