Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8022 | 8022-30813 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184I, L210W, T215Y | A62V | K103N | V108I | P4S, E6D, E53D, W88C, V90I, D123E, T139K, S162A, F171Y, I178L, T200K, I202V, R211K, T240K, A272P, K281R, L283I, T286P, I293V, E297K, H315HY, R356K, G359S, A371V |
| >8022-30813| codons 1-399 PISSIDTVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPDNPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFCEIQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKEFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSPAIFQASMTKILEPYRKQNPDLVI YQYIDDLYVGSDLEIGQHRKKVEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWK VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCRLIRGPKALTEVVPLTKEAE LELAENREILKEPVYGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A | K43T | E35D, M36I, R41K, I62V, L63P |
| >8022-30813| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGKWTPKMIVGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |