Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8021 | 8021-30806 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | L10F, K43T, G73S, L89V | V11L, T12N, I15V, L19LP, K20I, E35N, M36I, N37E, I62V, L63P, A71I, I72KR, V77I, I85V, I93L |
| >8021-30806| codons 1-99 PQITLWQRPFLNIKVGGQPIEALLDTGADDTVLENIELPGRWTPKIVGGIGGFMKVRQYD QVPIEICGHKIRSTVLIGPTPVNVVGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | Y181C | V108I | K20R, V35I, E44D, A98S, V118I, K122E, I135T, Q197L, E203K, Q207DE, H208HY, R211K, D218E, T286A, E297K, K311R, I326V, Q334L, G359S, A371I, A376S, K390R |
| >8021-30806| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLKKKKSVTILDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLEIGLHRTKIKELREYLWKWGFYTPENKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTEVIPLTKEAE LELAENREILREPVHGVYYDPSKDLVAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEIVQKISTESIVIWGKTPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |