Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8018 | 8018-30729 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | L24I, F53L | L10I, I13V, K20T, L33V, L63P, I64V |
| >8018-30729| codons 1-99 PQITLWQRPIVTVKIGGQLTEALIDTGADDTVVEEMNLPGRWKPKLIGGIGGLVKVRQYD QIPVEICGHKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K20R, E28K, V35I, K43N, D123E, E204Q, Q207A, R211K, S251N, A272P, K277R, I293V, I326V, I329V, G335S, F346FL, R358K, G359S, A371V, E399D |
| >8018-30729| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALIEICTELENEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEQLRAHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDNWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGQSQWTYQIYQEPLKNLKTGKYARMKSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWDA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |