<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8016 8016-30826 U.K. 2003 HIV1 D Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54L L10F, Q58E I13V, K20T, E35ED, M36I, N37ND, R41K, L63Q, I64V  
>8016-30826| codons 1-99
PQITLWQRPFVTVKIGGQLTEALLDTGADDTVLEDIDLPGKWKPKLIGGIGGFLKVREYD
QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, Y115F, M184V, L210W, T215Y V75I, K219E     V35T, T39I, K49R, V60I, I135V, D177E, I178M, T200R, Q207E, R211K, V245K, D250E, A272P, L282C, L283I, I293V, Q334QL, G335E, P345Q, F346Y, R356K, M357L, R358RK, A360T, V365I, E370A, I375V, T377Q, S379C, K390R, E399D T286G
>8016-30826| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIELEKEGKISRIGPENPYNTPI
FAIKKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL
DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYVDDLYVGSDLEIGQHRRKIEELREHLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT
VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCIRGGKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLEQWTYQIYQEQYKNLKTGKYAKLKGT
HTNDIKQLTAAVQKVAQECIVIWGKTPKFRLPIQKETWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006