Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8016 | 8016-30826 | U.K. | 2003 | HIV1 | D | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L | L10F, Q58E | I13V, K20T, E35ED, M36I, N37ND, R41K, L63Q, I64V |
| >8016-30826| codons 1-99 PQITLWQRPFVTVKIGGQLTEALLDTGADDTVLEDIDLPGKWKPKLIGGIGGFLKVREYD QIQVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, Y115F, M184V, L210W, T215Y | V75I, K219E | V35T, T39I, K49R, V60I, I135V, D177E, I178M, T200R, Q207E, R211K, V245K, D250E, A272P, L282C, L283I, I293V, Q334QL, G335E, P345Q, F346Y, R356K, M357L, R358RK, A360T, V365I, E370A, I375V, T377Q, S379C, K390R, E399D | T286G |
| >8016-30826| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICIELEKEGKISRIGPENPYNTPI FAIKKKDSTKWRKLIDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAFFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVGSDLEIGQHRRKIEELREHLWKWGFYTPDEKHQKEPPFLWMGYELHPDKWT VQPIKLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKCIRGGKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGLEQWTYQIYQEQYKNLKTGKYAKLKGT HTNDIKQLTAAVQKVAQECIVIWGKTPKFRLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |