Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8012 | 8012-30506 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11I, G73S, L89V | L5F, L10I, T12P, I13V, K14R, K20I, M36I, L63P, A71V, I93L |
| >8012-30506| codons 1-99 PQITFWQRPIIPVRIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYD QIPIEICGHKVISTVLVGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184I, L210W, T215Y | K219N | K103N | K43E, E44A, K82R, V118I, K122E, I135L, S162C, I178M, V179I, G196E, T200A, E203K, H208Y, R211K, K223Q, F227Y, K277R, Q278E, E312Q, V317A, Q334L, F346Y, G359S, A371V |
| >8012-30506| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPV FAIKKKNSTKWRKLMDFRELNRRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDMII YQYIDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTPDNKHQQEPPYLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRELCKLLRGTKALTEVIPLTEEAE LELAENREILKQPVHGAYYDPSKDLIAEIQKQGLGQWTYQIYQEPYKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |