Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8011 | 8011-30506 | U.K. | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V | L33F, F53L | I13V, K14R, K20T, M36I, N37D, R41K, L63LP, C67E, H69K, T74A, V82I, L89M | E35R |
| >8011-30506| codons 1-99 PQITLWQRPLVTVRIGGQLTEALLDTGADDTVFERIDLPGKWKPKIIGGVGGLIKVRQYD QIPIEIEGKKAIGAVLVGPTPINIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, T215Y | K219Q, N348I | Y181C | K101N, V108I | V8VG, K32Q, V35T, T39A, E44D, V60I, V118I, D121H, K122E, I135R, S162DN, K173V, Q174N, D177E, V179VA, T200A, I202V, Q207D, H221Y, V245Q, E248D, D250E, A272P, T286A, E291D, V292I, I293V, P321S, D324E, I329V, Q334L, G335D, P345Q, F346Y, R356K, M357R, R358G, G359S, T386V, K390R, Q394R, E399D | P9PL, A371GV |
| >8011-30506| codons 1-399 PISPIETGLVKLKPGMDGPKVKQWPLTEEKIQALTEICAELEKDGKISKIGPENPYNTPI FAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLNKKKSVTILDVGDAYFSIPL HEDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQNSMTKILEPFRVNNPEIAI CQYVDDLYVGSDLEIGQHRAKVEELRDHLLRWGFYTPDQKYQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDSSKELIAEVQKQGLDQWTYQIYQEQYKILKTGKYAKRGSA HTNDVKQLTEVVQKIATESIVIWGKVPKFRLPIRKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |