Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8008 | 8008-30715 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74I, M184V, L210W, T215Y | D67G | K103N, Y181C, G190A | A98G | K20R, K43N, E44ED, V111VIM, D123E, I135L, D177E, T200TA, R211K, Q278H, A288S, I293V, E297EQ, R358K, G359S, K366KN, T369TP, A371V, E396ED, E399D | V372VA |
| >8008-30715| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV FAIKKKGSDKWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDMGDAYFSVPL DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI CQYVDDLYVASDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGTKSLTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA HTNDVNQLPEVAQKIATESIVIWGKTPKFKLPIQKDTWD |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48A, I50V, I54V, V82A | L33F, F53L, Q58QE, T74P | L10I, L19I, E34Q, I62V, L63P, A71V, I93L |
| >8008-30715| codons 1-99 PQITLWQRPIVTIKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKIIAGVGGLVKVREYD QVPIEICGHKVIGPVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |