<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8008 8008-30715 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, G48A, I50V, I54V, V82A L33F, F53L, Q58QE, T74P L10I, L19I, E34Q, I62V, L63P, A71V, I93L  
>8008-30715| codons 1-99
PQITLWQRPIVTIKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKIIAGVGGLVKVREYD
QVPIEICGHKVIGPVLVGPTPANIIGRNLLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74I, M184V, L210W, T215Y D67G K103N, Y181C, G190A A98G K20R, K43N, E44ED, D123E, I135L, D177E, T200TA, R211K, Q278H, A288S, I293V, E297EQ, R358K, G359S, K366KN, T369TP, A371V, V372VA, E396ED, E399D V111VIM
>8008-30715| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELENDGKISKIGPENPYNTPV
FAIKKKGSDKWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDMGDAYFSVPL
DKEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI
CQYVDDLYVASDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKHLCKLLRGTKSLTEVVPLTQEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMKSA
HTNDVNQLPEVAQKIATESIVIWGKTPKFKLPIQKDTWD

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006