Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8007 | 8007-30624 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, K70R, Q151M | A62V, V75I, T215V, K219E | K101E, Y181C, G190A | V108I | S68G, K122E, I135T, I167V, R172RK, Q197K, T200E, E204G, E248D, D250E, I293V, P294Q, K311R, M357T, E370D |
| >8007-30624| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FVIKRKDGTRWRKLIDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTILDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKVLEPFKKQNPDIVI CQYMDDLYVASDLEIGKHREKIEGLRQHLLRWGFVTPDEKHQKEPPFLWMGYELHPDKWT VQPIVLPDKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVQLTEEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARTRGA HTNDVKQLTDAVQKIATESIVIWGKTPKFKLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A | L24I, L33F, F53L | L10V, T12P, L19Q, K20KM, N37S, R41K, R57K, I62V, L63P, I64V, H69Y |
| >8007-30624| codons 1-99 PQITLWQRPVVPIKIGGQQMEALIDTGADDTVFEEMSLPGKWKPKLIVGIGGLVKVKQYD QVPVEICGYKAIGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |