Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8006 | 8006-30527 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215F | A98G | T39K, K43E, V118I, K122E, D123N, I135T, I142IV, S162SADY, V179VI, I202IV, F214L, A272P, A288T, L289I, I293IV, E297K, K311R, A360T, K366KR | L234LP |
| >8006-30527| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICKELEEEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DENFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIII YQYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGLFTPDKKHQKEPPFLWMGYEPHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKTITEVVPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGT HTNDVRQLTEAVQKIATESIVIWGKTPKFKLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A, L90M | L10F, Q58E, G73S, L89V | I15V, Q18H, K20I, L24F, R41K, L63P, A71V, I72ILM, I93L |
| >8006-30527| codons 1-99 PQITLWQRPFVTIKVGGHLIEALFDTGADDTVLEEMNLPGKWKPKLIGGIGGFIKVREYD QIPIEICGHKVMSTVLVGPTPANIIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |