<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8005 8005-30513 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, K65KR, D67N, Q151M, M184MIV, L210W, T215Y A62V, V75I, F116Y, K219E Y181C, G190GA V108I V35VAIT, S68SG, V90I, A98S, K122E, I135IT, I167IV, E203K, Q207E, R211K, D218DE, K223KE, L228LH, V245Q, K277KR, T286A, P294T, E297K, E312EQ, D324E, Q334L, G359S, A371V, A376AT, K385R, T386TI, K390R  
>8005-30513| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV
FVIKRKNGTKWRKLIDFRELNKRTQDFWEIQLGIPHPSGLKKKKSVTILDVGDAYYSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKVLEPFRKQNPDIVI
CQYVDDLYVASDLEIGQHRTKIKELREHLWKWGFYTPEEKHQEEPPFHWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVITLTKEAE
LELAENREILKQPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA
HTNDVKQLTEVVQKITTESIVIWGRIPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V, L90M L10F, Q58QE L19LI, K20R, M36I, R41K, I62IV, L63P, A71V, Q92K, I93L, C95F  
>8005-30513| codons 1-99
PQITLWQRPFVTIKIGGQIREALLDTGADDTVLEEINLPGKWKPKLIGGIGGFVKVREYD
QVPIEICGHKVIGTVLVGPTPANVIGRNLMTKLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006