Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8005 | 8005-30513 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, I84V, L90M | L10F, Q58QE | L19LI, K20R, M36I, R41K, I62IV, L63P, A71V, Q92K, I93L, C95F |
| >8005-30513| codons 1-99 PQITLWQRPFVTIKIGGQIREALLDTGADDTVLEEINLPGKWKPKLIGGIGGFVKVREYD QVPIEICGHKVIGTVLVGPTPANVIGRNLMTKLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65KR, D67N, Q151M, M184MIV, L210W, T215Y | A62V, V75I, F116Y, K219E | Y181C, G190GA | V108I | V35VAIT, S68SG, V90I, A98S, K122E, I135IT, I167IV, E203K, Q207E, R211K, D218DE, K223KE, L228LH, V245Q, K277KR, T286A, P294T, E297K, E312EQ, D324E, Q334L, G359S, A371V, A376AT, K385R, T386TI, K390R |
| >8005-30513| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTELEKEGKISKIGPENPYNTPV FVIKRKNGTKWRKLIDFRELNKRTQDFWEIQLGIPHPSGLKKKKSVTILDVGDAYYSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKVLEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRTKIKELREHLWKWGFYTPEEKHQEEPPFHWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTEVITLTKEAE LELAENREILKQPVHGVYYDPSKELIAEIQKQGLGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKITTESIVIWGRIPKFRLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |