Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8004 | 8004-30514 | U.K. | 2003 | HIV1 | G | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K101KE, Y181YDFV | E28K, K32E, A98S, K122E, D123S, K173I, Q174QK, D177DE, V245LQ, E248D, D250DE, A272P, K277R, T286A, E291D, V292I, I293IV, E297A, L301M, D324E, L325I, I329V, Q334P, F346Y, R356K, M357K, R358G, G359S, A371IV, Q394R |
| >8004-30514| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI VQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE MELAENREILKEPVHGVYYDPSKEIIAEVQKQGPGQWTYQIYQEPYKNLKTGKYAKKGSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIRKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A | I13V, K20I, A22AV, E35D, M36I, R41K, R57K, L63P, I66F, A71V, T91A |
| >8004-30514| codons 1-99 PQITLWQRPLVTVKIGGQLIEVLLDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVKQYD QIPIEFCGHKVIGTVLVGPTPANIIGRNLLAQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |