<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8004 8004-30514 U.K. 2003 HIV1 G Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, L210W, T215Y   K101KE, Y181YDFV   E28K, K32E, A98S, K122E, D123S, K173I, Q174QK, D177DE, V245LQ, E248D, D250DE, A272P, K277R, T286A, E291D, V292I, I293IV, E297A, L301M, D324E, L325I, I329V, Q334P, F346Y, R356K, M357K, R358G, G359S, A371IV, Q394R  
>8004-30514| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTKEKIEALVEICTELEKEGKISKIGPENPYNTPV
FAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPSGLEKKKSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRIKNPEIVI
VQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPDKESWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGAKALTDIVPLTAEAE
MELAENREILKEPVHGVYYDPSKEIIAEVQKQGPGQWTYQIYQEPYKNLKTGKYAKKGSA
HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIRKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A   I13V, K20I, A22AV, E35D, M36I, R41K, R57K, L63P, I66F, A71V, T91A  
>8004-30514| codons 1-99
PQITLWQRPLVTVKIGGQLIEVLLDTGADDTVLEDINLPGKWKPKLIGGIGGFVKVKQYD
QIPIEFCGHKVIGTVLVGPTPANIIGRNLLAQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006