<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-8003 8003-30501 U.K. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, D67N, Y115F, Q151M, M184V A62V, V75I, F77L K103S, G190A K238KT T58N, T69S, V106VI, K122E, I135T, Q207K, R211A, F214L, K219G, K249Q, K275Q, I293V, E297K, I326V, Q334EK, A355S, R356K, K366R, T369A, A376V, T386AV A33IV
>8003-30501| codons 1-399
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKVLVEICTEMEKEGKISKIGPENPYNNPV
FVIKRKNSSKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKSKSITVLDVGDAFFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLYVASDLEIGQHRTKIEELRKHLLAWGLTTPDGKHQKEPPFLWMGYELHPDTWT
VQPIVLPEQDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLVAEIQKQGKGQWTYQIYQEPFKNLKTGKYSKMRGA
HTNDVRQLAEAVQKIVTESIVIWGKVPKFKLPIQKETWE

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48V, I54T, V82A, L90M L33F, Q58E L10I, I13V, K20R, E34N, E35D, M36I, N37D, I62V, L63P, A71T, I93M  
>8003-30501| codons 1-99
PQITLWQRPIVTVKIGGQLREALLDTGADDTVFNDIDLPGRWKPKMIVGIGGFTKVREYD
QVPIEICGHKTIGTVLVGPTPANIIGRNLMTQMGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006