Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8003 | 8003-30501 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54T, V82A, L90M | L33F, Q58E | L10I, I13V, K20R, E34N, E35D, M36I, N37D, I62V, L63P, A71T, I93M |
| >8003-30501| codons 1-99 PQITLWQRPIVTVKIGGQLREALLDTGADDTVFNDIDLPGRWKPKMIVGIGGFTKVREYD QVPIEICGHKTIGTVLVGPTPANIIGRNLMTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, D67N, Y115F, Q151M, M184V | A62V, V75I, F77L | K103S, G190A | K238KT | T58N, T69S, V106VI, K122E, I135T, Q207K, R211A, F214L, K219G, K249Q, K275Q, I293V, E297K, I326V, Q334EK, A355S, R356K, K366R, T369A, A376V, T386AV | A33IV |
| >8003-30501| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKVLVEICTEMEKEGKISKIGPENPYNNPV FVIKRKNSSKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKSKSITVLDVGDAFFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVASDLEIGQHRTKIEELRKHLLAWGLTTPDGKHQKEPPFLWMGYELHPDTWT VQPIVLPEQDSWTVNDIQKLVGKLNWASQIYAGIQVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLVAEIQKQGKGQWTYQIYQEPFKNLKTGKYSKMRGA HTNDVRQLAEAVQKIVTESIVIWGKVPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |