Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-8001 | 8001-30410 | U.K. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L10I, L19T, K20R, M36I, K55R, R57K, I62V, L63P, A71V, I93L |
| >8001-30410| codons 1-99 PQITLWQRPIVTIKIGGQTREALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVRVKQYD QVPIEICGHKVIGTVVVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, T215F | K219E, N348I | Y181C, G190A | T69TN, K122E, D123N, S162C, T165TI, E169ED, I178M, V179I, Q207E, H208Y, R211RK, K223Q, L228H, P243PT, A272P, K277KR, I293V, S322T, A376V, K390R |
| >8001-30410| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMIKILDPFRKQNPDMII CQYMDDLYVASDLEIGQHRTKIEELREYLLKWGFFTPDEKHQQEPPFHWMGYELHPDKWT VQTIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPTKDLIAEIQKQGQGQWTYQIYQEPFKILKTGKYARMRGA HTNDVKQLTEAVQKIVTESIVIWGKTPKFRLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |