Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7232 | 7232-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MIV, I54V, V82T, I84V, L90M | Q58E | L10I, K14KR, K20R, E35D, M36I, N37DE, I62V, L63P, A71IV |
| >7232-30930| codons 1-99 PQITLWQRPIVTIRIGGQLREALLDTGADDTVLEDIELPGRWKPKVIGGIGGFVKVREYD QVPIEICGHKVIGTVLVGPTPTNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184MI, T215F | K219Q | V35T, T39A, V60VI, T69E, K101KQ, V118I, K122E, Q174QR, I178IM, V179VI, R211T, F214L, K223KQ, L228LF, A272P, L283I, I293V, E297K, K311R, G333E, Y339W, R356K, A371V |
| >7232-30930| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAELEKEGKISKIGPENPYNTPI FAIKKKNSERWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKRNPDMII YQYIDDLYVGSDLEIGQHRTKIEELRQHLLTWGLFTPDQKHQQEPPFFWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLIRGTKALTEVVPLTKEAE LELAENREILREPVHGVYYDPSKDLIAEIQKQEQGQWTWQIYQEPFKNLKTGKYAKMRGA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |