<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7231 7231-30930 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, M184V, L210W, T215Y D67G, K219R K101E, G190A F227L P4ST, K43Q, E44D, E53D, W88C, V118I, K122P, D177E, I178M, T200A, E203K, L205F, Q207D, H208Y, R211K, K223E, L228H, A272P, K277R, E297A, G333E, Q334H, R356K, G359S, T386I, K390R  
>7231-30930| codons 1-400
PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPDNPYNTPV
FAIKKKGSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL
DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI
YQYVDDLYVASDLEIGQHRAKIKEFRDYLWKWGFYTPDRKHQEEPPLHWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRSA
HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54AV, V82A L24I, L33F, F53L L10I, I13V, G16E, E34EQ, M36L, N37NS, K55KR, I62V, L63C, A71AV, I72V, T74A, L89I  
>7231-30930| codons 1-99
PQITLWQRPIVTVKIEGQLKEALIDTGADDTVFQELSLPGRWKPKMIGGIGGLVRVRQYD
QVCIEICGHKVVGAVLVGPTPANIIGRNILTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006