Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7231 | 7231-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, M184V, L210W, T215Y | D67G, K219R | K101E, G190A | F227L | P4ST, K43Q, E44D, E53D, W88C, V118I, K122P, D177E, I178M, T200A, E203K, L205F, Q207D, H208Y, R211K, K223E, L228H, A272P, K277R, E297A, G333E, Q334H, R356K, G359S, T386I, K390R |
| >7231-30930| codons 1-400 PISTIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEQDGKISKIGPDNPYNTPV FAIKKKGSDKWRKLVDFRELNKRTQDFCEVQLGIPHPAGLEKKKSVTVLDVGDAYFSIPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYVDDLYVASDLEIGQHRAKIKEFRDYLWKWGFYTPDRKHQEEPPLHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTAEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQEHGQWTYQIYQEPFKNLKTGKYAKMRSA HTNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54AV, V82A | L24I, L33F, F53L | L10I, I13V, G16E, E34EQ, M36L, N37NS, K55KR, I62V, L63C, A71AV, I72V, T74A, L89I |
| >7231-30930| codons 1-99 PQITLWQRPIVTVKIEGQLKEALIDTGADDTVFQELSLPGRWKPKMIGGIGGLVRVRQYD QVCIEICGHKVVGAVLVGPTPANIIGRNILTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |