<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7230 7230-30930 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y   G190A K101H K43N, E44D, K49R, V118I, K122E, I135V, S162C, E169D, V179VI, T200A, R211K, V245Q, A272P, K277R, L283I, K287KR, I293V, P294S, E297K, I329V, Q334L, K350R, R356K, G359S, A371V, T377Q  
>7230-30930| codons 1-400
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISRIGPENPYNTPV
FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL
DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDIII
YQYVDDLYVASDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTRALTEVVSLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLRTGKYAKMRSA
HTNDVKQLTEVVQKIAQESIVIWGKTPKFKLPIQKETWEA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L33F, G73S L10I, T12P, K20T, L63P, I66V, H69R, V77I, I93L, C95F  
>7230-30930| codons 1-99
PQITLWQRPIVPIKIGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYD
QIPIEVCGRKAISTVLIGPTPVNVIGRNLMTQLGFTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006