Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7230 | 7230-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33F, G73S | L10I, T12P, K20T, L63P, I66V, H69R, V77I, I93L, C95F |
| >7230-30930| codons 1-99 PQITLWQRPIVPIKIGGQLTEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGFVKVRQYD QIPIEVCGRKAISTVLIGPTPVNVIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | G190A | K101H | K43N, E44D, K49R, V118I, K122E, I135V, S162C, E169D, V179VI, T200A, R211K, V245Q, A272P, K277R, L283I, K287KR, I293V, P294S, E297K, I329V, Q334L, K350R, R356K, G359S, A371V, T377Q |
| >7230-30930| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENDGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLHKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPDIII YQYVDDLYVASDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLIRGTRALTEVVSLTKEAE LELAENREILKEPVHGVYYDPSKDLIAEVQKQGLGQWTYQIYQEPFKNLRTGKYAKMRSA HTNDVKQLTEVVQKIAQESIVIWGKTPKFKLPIQKETWEA |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |