<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
48-7229 7229-30930 Spain 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, K70R, M184V, T215F V75VM, K219Q K101P, K103S   K20R, E28K, K32E, V60I, T69N, K122E, I135T, S162CY, D177E, V179I, D192N, T200E, F214L, D218E, A272P, I293V, E297K, I329L, G333E, R356K, A360V, E399D  
>7229-30930| codons 1-399
PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALVEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSNRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLPKSKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIII
YQYVDDLYVGSNLEIGQHREKIEELRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYAKMRGV
HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWD

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47A, L90M V11I, G73S L10I, T12S, I13V, I15V, K20I, E34K, M36I, N37S, R41K, I62V, L63P, A71T, I72T  
>7229-30930| codons 1-99
PQITLWQRPIISVKVGGQLIEALLDTGADDTILKEISLPGKWKPKMAGGIGGFIKVRQYD
QVPIEICGHKTTSTVLVGPTPVNIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006