Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7229 | 7229-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47A, L90M | V11I, G73S | L10I, T12S, I13V, I15V, K20I, E34K, M36I, N37S, R41K, I62V, L63P, A71T, I72T |
| >7229-30930| codons 1-99 PQITLWQRPIISVKVGGQLIEALLDTGADDTILKEISLPGKWKPKMAGGIGGFIKVRQYD QVPIEICGHKTTSTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | V75VM, K219Q | K101P, K103S | K20R, E28K, K32E, V60I, T69N, K122E, I135T, S162CY, D177E, V179I, D192N, T200E, F214L, D218E, A272P, I293V, E297K, I329L, G333E, R356K, A360V, E399D |
| >7229-30930| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIEALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLPKSKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPEIII YQYVDDLYVGSNLEIGQHREKIEELRQHLLRWGLFTPEQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIYQEPFKNLKTGKYAKMRGV HTNDVKQLTEAVQKIATESIVIWGKTPKFKLPIQKETWD |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |