Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7226 | 7226-30828 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, L210W, T215Y | K219KN | Y181C | K20R, V35T, T39A, S48T, V60I, T69TA, V118VI, K122E, I135T, E203K, Q207E, R211K, A272P, I293V, E297R, G359S, A371V, K390R |
| >7226-30828| codons 1-400 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICAELEKEGKITKIGPENPYNTPI FAIKKKDSAKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYMDDLYVGSDLEIGQHRTKIKELREHLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTREAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFRLPIQKETWEA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54LV, V82A, I84V | L24I, K43T | L10I, T12N, K20R, E35D, M36I, L63P, A71V, I93L |
| >7226-30828| codons 1-99 PQITLWQRPIVNIKIGGQLREALIDTGADDTVLEDINLPGRWTPKIIGGIGGFVKVRQYD QIPIEICGHKVIGTVLVGPTPANVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |