Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7213 | 7213-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, V82A, L90M | L10F, V11I, L33F, K43T, F53L, L89V | I13V, E35D, M36L, N37V, K55KR, L63P, A71V, Q92QK |
| >7213-30930| codons 1-99 PQITLWQRPFITVKIGGQLKEALLDTGADDTIFEDLVLPGRWTPKIVGGIGGLLRVRQYD QIPIEICGHKVIGTVLVGPTPANIIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K103N, Y181C, G190A | A98G, F227L | K20R, V35I, K43E, E44A, K64R, V118I, K122E, T200A, E203K, H208Y, R211K, K223E, L228H, Q242L, R284K, T286A, E297R, E312Q, D324E, I329L, T377L, K395R |
| >7213-30930| codons 1-399 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEAGKISKIGPENPYNTPV FAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHPGGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVASDLEIGQHRAKIKELRQYLWKWGFYTPDNKHQEEPPLHWMGYELHPDKWT VLPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLKGAKALTEVIPLTREAE LELAENREILKQPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEAVQKIALESIVIWGKTPKFKLPIQRETWE |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |