Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 48-7211 | 7211-30930 | Spain | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A | L24I, L33I, K43T, G73T | L10I, Q18H, K20R, E35D, M36I, L63P, I64V, A71V, I72M |
| >7211-30930| codons 1-99 PQITLWQRPIVTIKIGGHLREALIDTGADDTVIEDINLPGRWTPKIIGGIGGFVKVRQYD QIPVEICGHKVMTTVLVGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, L74I, M184V, T215F | V75A, K219Q, N348I | K103N, Y181C | V179F | E6D, V35I, K102KR, I135T, I202IV, D218E, L228H, D250E, A272P, I293V, P294ST, E297K, I329L, G333DE, Y342F, R356K, M357R, A360V, T386TI, K390R, A400AT |
| >7211-30930| codons 2-400 ISPIDTVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPENPYNTPVF AIKKKNSDRWRKIADFRELNKRTQDFWEVQLGIPHPAGLKRNKSVTVLDVGDAYFSVPLD KDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIFIC QYVDDLYVGSDLEIGQHRTKVEELRQHLLRWGFFTPEQKHQKEPPFHWMGYELHPDKWTV QPIVLPEKESWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVTLTKEAEL ELAENREILKEPVHGVYYDPSKDLIAELQKQEQGQWTYQIFQEPFKILKTGKYAKRRGVH TNDVKQLTEAVQKIATESIVIWGKIPKFRLPIQKETWET |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |